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BISPECIFIC ANTIBODIES
Descriptors Found:
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DeCS
Descriptor
English
:
Antibodies, Bispecific
Descriptor
Spanish
:
Anticuerpos Biespecíficos
Descriptor
Portuguese
:
Anticorpos Biespecíficos
Synonyms
English
:
Bifunctional Antibodies
Bispecific Antibodies
Tree Number:
D12.776.124.486.485.114.125
D12.776.124.790.651.114.134
D12.776.377.715.548.114.134
Definition
English
:
Antibodies
, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial
antibodies
produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular
genetic techniques
. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled
haptens
, and effector cells to diseased tissue, primarily tumors.
Indexing Annotation
English
:
do not coordinate with
ANTIBODY FORMATION
for
/biosynthesis
Pharmacological Action:
Immunologic Factors
See Related
English
:
Immunotoxins
Radioimmunotherapy
History Note
English
:
94
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
31649
Unique Identifier:
D018033
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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